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Year Number of Results
1963 1
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1965 10
1966 3
1967 5
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1969 4
1970 18
1971 42
1972 51
1973 43
1974 52
1975 90
1976 86
1977 65
1978 61
1979 66
1980 57
1981 36
1982 57
1983 46
1984 41
1985 42
1986 52
1987 52
1988 72
1989 70
1990 69
1991 102
1992 105
1993 98
1994 118
1995 146
1996 125
1997 149
1998 146
1999 179
2000 187
2001 185
2002 188
2003 239
2004 264
2005 282
2006 329
2007 307
2008 372
2009 377
2010 353
2011 368
2012 399
2013 410
2014 460
2015 401
2016 399
2017 407
2018 377
2019 414
2020 737
2021 980
2022 822
2023 582
2024 205

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Page 1
Structures of dengue virus RNA replicase complexes.
Osawa T, Aoki M, Ehara H, Sekine SI. Osawa T, et al. Mol Cell. 2023 Aug 3;83(15):2781-2791.e4. doi: 10.1016/j.molcel.2023.06.023. Epub 2023 Jul 20. Mol Cell. 2023. PMID: 37478848 Free article.
Dengue is a mosquito-borne viral infection caused by dengue virus (DENV), a member of the flaviviruses. The DENV genome is a 5'-capped positive-sense RNA with a unique 5'-stem-loop structure (SLA), which is essential for RNA replication and 5' capping. ...Here, we r …
Dengue is a mosquito-borne viral infection caused by dengue virus (DENV), a member of the flaviviruses. The DENV genome is a 5'-capped posit …
Organization of the Flavivirus RNA replicase complex.
Brand C, Bisaillon M, Geiss BJ. Brand C, et al. Wiley Interdiscip Rev RNA. 2017 Nov;8(6):10.1002/wrna.1437. doi: 10.1002/wrna.1437. Epub 2017 Aug 16. Wiley Interdiscip Rev RNA. 2017. PMID: 28815931 Free PMC article. Review.
NS3 and NS5 interact within virus-induced replication compartments to form the RNA genome replicase complex. Although the individual enzymatic activities of both proteins have been extensively studied and are well characterized, there are still gaps in our understan …
NS3 and NS5 interact within virus-induced replication compartments to form the RNA genome replicase complex. Although the indi …
RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro.
Levanova AA, Vainio EJ, Hantula J, Poranen MM. Levanova AA, et al. Viruses. 2021 Aug 31;13(9):1738. doi: 10.3390/v13091738. Viruses. 2021. PMID: 34578320 Free PMC article.
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae. The purpose of the study was to determine the biochemical requirements for RNA s …
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orth …
Composition of plant virus RNA replicase complexes.
Mine A, Okuno T. Mine A, et al. Curr Opin Virol. 2012 Dec;2(6):669-75. doi: 10.1016/j.coviro.2012.09.014. Epub 2012 Oct 18. Curr Opin Virol. 2012. PMID: 23083891 Review.
The replication of the genome of positive-strand RNA viruses depends on their own RNA replicase complexes. Substantial advances in the experimental approaches used to determine the composition of the viral replicase complexes revealed that the repli …
The replication of the genome of positive-strand RNA viruses depends on their own RNA replicase complexes. Substantial …
Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus.
Lello LS, Miilimäe A, Cherkashchenko L, Omler A, Skilton R, Ireland R, Ulaeto D, Merits A. Lello LS, et al. J Virol. 2023 Jan 31;97(1):e0136822. doi: 10.1128/jvi.01368-22. Epub 2022 Dec 19. J Virol. 2023. PMID: 36533950 Free PMC article.
P1234 undergoes a series of precise cleavage events producing four nonstructural proteins (nsP1-4) representing subunits of the RNA replicase. Here, we report the construction and properties of a trans-replicase for EEEV. ...The ability of EEEV P123 to form f …
P1234 undergoes a series of precise cleavage events producing four nonstructural proteins (nsP1-4) representing subunits of the RNA …
nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity.
Lello LS, Bartholomeeusen K, Wang S, Coppens S, Fragkoudis R, Alphey L, Ariën KK, Merits A, Utt A. Lello LS, et al. J Virol. 2021 Sep 27;95(20):e0035521. doi: 10.1128/JVI.00355-21. Epub 2021 Jul 28. J Virol. 2021. PMID: 34319783 Free PMC article.
Alphaviruses have positive-strand RNA genomes containing two open reading frames (ORFs). The first ORF encodes the nonstructural (ns) polyproteins P123 and P1234 that act as precursors for the subunits of the viral RNA replicase (nsP1 to nsP4). Processing of …
Alphaviruses have positive-strand RNA genomes containing two open reading frames (ORFs). The first ORF encodes the nonstructural (ns) …
In search of an RNA replicase ribozyme.
McGinness KE, Joyce GF. McGinness KE, et al. Chem Biol. 2003 Jan;10(1):5-14. doi: 10.1016/s1074-5521(03)00003-6. Chem Biol. 2003. PMID: 12573693 Free article. Review.
The theory that an RNA world played a pivotal role in life's evolutionary past has prompted investigations into the scope of RNA catalysis. ...These experiments demonstrate that RNA replicase behavior is likely within the catalytic repertoire of RNA …
The theory that an RNA world played a pivotal role in life's evolutionary past has prompted investigations into the scope of RNA …
Intramolecular RNA replicase: possibly the first self-replicating molecule in the RNA world.
Ma W, Yu C. Ma W, et al. Orig Life Evol Biosph. 2006 Aug;36(4):413-20. doi: 10.1007/s11084-005-9006-1. Epub 2006 Aug 15. Orig Life Evol Biosph. 2006. PMID: 16909330 Review.
Usually it is speculated that it originated from a prebiotic nucleotide pool, during which a self-replicating RNA synthesis ribozyme may have emerged as the first ribozyme - the RNA replicase. ...Thus the RNA molecule could self-replicate and be referr …
Usually it is speculated that it originated from a prebiotic nucleotide pool, during which a self-replicating RNA synthesis ribozyme …
Flavivirus RNA synthesis in vitro.
Padmanabhan R, Takhampunya R, Teramoto T, Choi KH. Padmanabhan R, et al. Methods. 2015 Dec;91:20-34. doi: 10.1016/j.ymeth.2015.08.002. Epub 2015 Aug 10. Methods. 2015. PMID: 26272247 Free PMC article. Review.
Establishment of in vitro systems to study mechanisms of RNA synthesis for positive strand RNA viruses have been very useful in the past and have shed light on the composition of protein and RNA components, optimum conditions, the nature of the products forme …
Establishment of in vitro systems to study mechanisms of RNA synthesis for positive strand RNA viruses have been very useful i …
Protein-RNA Interactions in the Single-Stranded RNA Bacteriophages.
Rūmnieks J, Tārs K. Rūmnieks J, et al. Subcell Biochem. 2018;88:281-303. doi: 10.1007/978-981-10-8456-0_13. Subcell Biochem. 2018. PMID: 29900502 Review.
Bacteriophages of the Leviviridae family are small viruses with short single-stranded RNA (ssRNA) genomes. Protein-RNA interactions play a key role throughout the phage life cycle, and all of the conserved phage proteins - the maturation protein, the coat protein an …
Bacteriophages of the Leviviridae family are small viruses with short single-stranded RNA (ssRNA) genomes. Protein-RNA interac …
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